Publication

~2018 selected publications                                     *Corresponding author

1.      Yokoyama U*, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, and Ishikawa Y. Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm. Am J Physiol Heart Circ Physiol, 2018. 315: H1012-H1018. DOI:10.1152/ajpheart.00329.2018.

2.      Saito J, Yokoyama U*, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, and Ishikawa Y. Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus. PLoS One, 2018. 13: e0190871. DOI:10.1371/journal.pone.0190871.

3.      Masuda T, Ukiki M, Yamagishi Y, Matsusaki M, Akashi M, Yokoyama U, and Arai F. Fabrication of engineered tubular tissue for small blood vessels via three-dimensional cellular assembly and organization ex vivo. J Biotechnol, 2018. 276-277: 46-53. DOI:10.1016/j.jbiotec.2018.04.003.

4.      Mamun A, Yokoyama U*, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, and Ishikawa Y. A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm. Physiol Rep, 2018. 6: e13878. DOI:10.14814/phy2.13878.

5.      Yokoyama U*, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, and Ishikawa Y. Arterial graft with elastic layer structure grown from cells. Sci Rep, 2017. 7: 140. DOI:10.1038/s41598-017-00237-1.

6.      Yokoyama U*, Ichikawa Y, Minamisawa S, and Ishikawa Y. Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosus. J Physiol Sci, 2017. 67: 259-270. DOI:10.1007/s12576-016-0512-x.

7.      Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, and Goshima Y. L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. JCI Insight, 2017. 2. DOI:10.1172/jci.insight.90903.

8.      Jin H, Fujita T, Jin M, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, and Ishikawa Y. Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway. J Mol Cell Cardiol, 2017. 108: 170-180. DOI:10.1016/j.yjmcc.2017.05.014.

9.      Ito S, Yokoyama U*, Saito J, Sato S, Usuda H, Watanabe S, Kitanishi R, Miura Y, Saito M, Hanita T, Matsuda T, and Ishikawa Y. Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons. J Physiol Sci, 2017. 67: 723-729. DOI:10.1007/s12576-017-0565-5.

10.   Fujita T, Umemura M, Yokoyama U, Okumura S, and Ishikawa Y. The role of Epac in the heart. Cell Mol Life Sci, 2017. 74: 591-606. DOI:10.1007/s00018-016-2336-5.

11.   Akagi S, Nakamura K, Yokoyama U, Kasahara S, Sarashina T, Ejiri K, and Ito H. Enhanced EP4 Expression in a Pulmonary Artery Aneurysm With Dissection in a Patient With Pulmonary Arterial Hypertension. Circ Cardiovasc Imaging, 2017. 10. DOI:10.1161/CIRCIMAGING.116.005839.

12.   Mochida S, Hida Y, Tanifuji S, Hagiwara A, Hamada S, Abe M, Ma H, Yasumura M, Kitajima I, Sakimura K and Ohtsuka T. SAD-B phosphorylation of CAST controls active zone vesicle recycling for synaptic depression. Cell Rep, 2016. 16: 2901-2913. DOI:10.1016/j.celrep.2016.08.020.

13.   Yokoyama U*. Prostaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus. Pediatr Int, 2015. 57: 820-827. DOI:10.1111/ped.12769.

14.   Kato Y, Yokoyama U*, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, and Ishikawa Y. Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation. Arterioscler Thromb Vasc Biol, 2015. 35: 2617-2625. DOI:10.1161/ATVBAHA.115.306534.

15.   Hayashida M, Tanifuji S, Ma H, Murakami N and Mochida S. Neural activity selects myosin IIB and VI with a specific time window in distinct dynamin isoform-mediated synaptic vesicle reuse pathways. J Neurosci, 2015. 35: 8901-8913. DOI:10.1523/JNEUROSCI.5028-14.2015.

16.   Vogl C, Tanifuji S, Danis B, Daniels V, Foerch P Wolff C, Whalley BJ, Mochida S and Stephens GJ. Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses. Eur J Neurosci, 2015. 41: 398-409. DOI:10.1111/ejn.12799.

17.   Yokoyama U, Minamisawa S, Shioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, and Ishikawa Y. Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling. Circulation, 2014. 129: 487-496. DOI:10.1161/CIRCULATIONAHA.113.004726.

18.   Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, and Ishikawa Y. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J Clin Invest, 2014. 124: 2785-2801. DOI:10.1172/JCI64784.

19.   Ishiwata R, Yokoyama U*, Matsusaki M, Asano Y, Kadowaki K, Ichikawa Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Akashi M, and Ishikawa Y. Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies. Atherosclerosis, 2014. 233: 590-600. DOI:10.1016/j.atherosclerosis.2014.01.045.

20.   Aoki R, Yokoyama U*, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, and Ishikawa Y. Decreased serum osmolality promotes ductus arteriosus constriction. Cardiovasc Res, 2014. 104: 326-336. DOI:10.1093/cvr/cvu199.

21.   Tashiro M, Inoue H, Konishi M. Physiological pathway of magnesium influx in rat ventricular myocytes. Biophys J 2014. 107:2049-2058. DOI:10.1016/j.bpj.2014.09.015.

22.   Islam Z, Hayashi N, Inoue H, Umezawa T, Kimura Y, Doi H, Romero MF, Hirose S, Kato A. Identification and lateral membrane localization of cyclin M3, likely to be involved in renal Mg²⁺ handling in seawater fish. Am J Physiol Regul Integr Comp Physiol, 2014. 307: R525-R537. DOI:10.1152/ajpregu.00032.

23.   Inoue H, Murayama T, Tashiro M, Sakurai T, Konishi M. Mg²⁺- and ATP-dependent inhibition of transient receptor potential melastatin 7 by oxidative stress. Free Rad Biol Med, 2014. 72: 257-266. DOI:10.1016/j.freeradbiomed.2014.04.015

24.   Odagiri F, Inoue H, Sugihara M, Suzuki T, Murayama T, Shioya T, Konishi M, Nakazato Y, Daida H, Sakurai T, Morimoto S, Kurebayashi N. Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice. PLoS One, 2014. 9: e101838. DOI:10.1371/journal.pone.0101838.  

25.   Saito R, Takahashi R, Sawabe E, Koyano S, Takahashi Y, Shima M, Ushizawa H, Fujie T, Tosaka N, Kato Y, Moriya K, Tohda S, Tojo N, Koike R, and Kubota T. First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan. Antimicrob Agents Chemother, 2014. 58: 2961-2963. DOIi: 10.1128/AAC.02072-13.

26.   Mori M, Tanifuji S and Mochida S. Kinetic organization of Ca²⁺ signals that regulate synaptic release efficacy in sympathetic neurons. Mol Pharmacol, 2014. 86: 297-305. DOI:10.1124/mol.114.094029.

27.   Yokoyama U, Iwatsubo K, Umemura M, Fujita T, and Ishikawa Y. The prostanoid EP4 receptor and its signaling pathway. Pharmacol Rev, 2013. 65: 1010-1052. DOI:10.1124/pr.112.007195.

28.   Tashiro M, Inoue H, Konishi M. Magnesium homeostasis in cardiac myocytes of Mg-deficient rats. PLoS One, 2013. 8:e73171. DOI:10.1371/journal.pone.0073171.

29.   Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, Yamada H, Halbritter J, Seki G, Konishi M, Zhou W, Yamane T, Murakami S, Caridi G, Ghiggeri G, Abe T, Hildebrandt F. Mutation of the Mg²⁺ transporter SLC41A1 results in a nephronophthisis-like phenotype. J Am Soc Nephrol, 2013. 24: 967-77. DOI:10.1681/ASN.2012101034.

30.   Tanifuji S, Funakoshi-Tago M, Ueda F, Kasahara T and Mochida S. Dynamin isoforms decode action potential firing for synaptic vesicle recycling. J Biol Chem, 2013. 288: 19050-19059. DOI:10.1074/jbc.M112.445874.

31.   Yokoyama U*, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, and Ishikawa Y. Inhibition of EP4 signaling attenuates aortic aneurysm formation. PLoS One, 2012. 7: e36724. DOI:10.1371/journal.pone.0036724.

32.   Matsusaki M, Kadowaki K, Adachi E, Sakura T, Yokoyama U, Ishikawa Y, and Akashi M. Morphological and histological evaluations of 3D-layered blood vessel constructs prepared by hierarchical cell manipulation. J Biomater Sci Polym Ed, 2012. 23: 63-79. DOI:10.1163/092050610X541953.

33.   Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, and Aroonsakool N. cAMP and Epac in the regulation of tissue fibrosis. Br J Pharmacol, 2012. 166: 447-456. DOI:10.1111/j.1476-5381.2012.01847.x.

34.   Ichikawa Y, Yokoyama U*, Iwamoto M, Oshikawa J, Okumura S, Sato M, Yokota S, Masuda M, Asou T, and Ishikawa Y. Inhibition of phosphodiesterase type 3 dilates the rat ductus arteriosus without inducing intimal thickening. Circ J, 2012. 76: 2456-2464. DOI:10.1253/circj.cj-12-0215.

35.   Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, and Ishikawa Y. Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. Circ Res, 2010. 106: 1882-1892. DOI:10.1161/CIRCRESAHA.109.214924.

36.   Yokoyama U, Minamisawa S, and Ishikawa Y. Regulation of vascular tone and remodeling of the ductus arteriosus. J Smooth Muscle Res, 2010. 46: 77-87. DOI:10.1540/jsmr.46.77.

37.   Suzuki S, Yokoyama U*, Abe T, Kiyonari H, Yamashita N, Kato Y, Kurotani R, Sato M, Okumura S, and Ishikawa Y. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem, 2010. 285: 24248-24259. DOI:10.1074/jbc.M109.094581.

38.   Tashiro M, Inoue H, Konishi M. KB-R7943 inhibits Na⁺-dependent Mg²⁺ efflux in rat ventricular myocytes. J Physiol Sci, 2010. 60:415-424DOI:10.1007/s12576-010-0113-z

39.   Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H and Kasahara T. Licochalcones suppress degranulation by decreasing the intracellular Ca²⁺ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol, 2010. 10: 769-776. DOI:10.1016/j.intimp.2010.04.007.

40.   Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, and Minamisawa S. T-type Ca²⁺ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation. J Biol Chem, 2009. 284: 24025-24034. DOI:10.1074/jbc.M109.017061.

41.   Inoue H, Takahashi N, Okada Y, Konishi M. Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice. Am J Physiol Cell Physiol, 2010. 298: C900-C909. DOI:10.1152/ajpcell.00450.2009. 

42.   Tanaka H, Hirose H, Kato Y, Kida S, and Miyajima E. Clinical evaluation of TRCRapid M.TB for detection of Mycobacterium tuberculosis complex in respiratory and nonrespiratory specimens. J Clin Microbiol. 2010. 48: 1536-1541. DOI:10.1128/JCM.01758-09.

43.   Tashiro M, Inoue H, Konishi M. Metabolic inhibition strongly inhibits Na⁺-dependent Mg²⁺ efflux in rat ventricular myocytes. Biophys J, 2009. 96:4941-4950 DOI:10.1016/j.bpj.2009.02.013.

44.   Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, and Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A, 2008. 105: 6386-6391. DOI:10.1073/pnas.0801490105.

45.   Yokoyama U, Minamisawa S, Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato M, and Ishikawa Y. Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A. J Biol Chem, 2008. 283: 28702-28709. DOI:10.1074/jbc.M804223200.

46.   Yokoyama U, Minamisawa S, Quan H, Akaike T, Jin M, Otsu K, Ulucan C, Wang X, Baljinnyam E, Takaoka M, Sata M, and Ishikawa Y. Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration. Am J Physiol Heart Circ Physiol, 2008. 295: H1547-1555. DOI:10.1152/ajpheart.01317.2007.

47.   Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, and Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation, 2008. 118: 1979-1988. DOI:10.1161/CIRCULATIONAHA.108.788331.

48.   Yokoyama U, Sato Y, Akaike T, Ishida S, Sawada J, Nagao T, Quan H, Jin M, Iwamoto M, Yokota S, Ishikawa Y, and Minamisawa S. Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus. Physiol Genomics, 2007. 31: 139-157. DOI:10.1152/physiolgenomics.00007.2006.

49.   Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, and Insel PA. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J, 2007. 21: 2970-2979. DOI:10.1096/fj.07-8424com.

50.   Yokoyama U, Minamisawa S, Quan H, Ghatak S, Akaike T, Segi-Nishida E, Iwasaki S, Iwamoto M, Misra S, Tamura K, Hori H, Yokota S, Toole BP, Sugimoto Y, and Ishikawa Y. Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J Clin Invest, 2006. 116: 3026-3034. DOI:10.1172/JCI28639.

51.   Yokoyama U, Minamisawa S, Adachi-Akahane S, Akaike T, Naguro I, Funakoshi K, Iwamoto M, Nakagome M, Uemura N, Hori H, Yokota S, and Ishikawa Y. Multiple transcripts of Ca2+ channel alpha1-subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus. Am J Physiol Heart Circ Physiol, 2006. 290: H1660-1670. DOI:10.1152/ajpheart.00100.2004.

52.   Tashiro M, Tursun P, Miyazaki T, Watanabe M, Konishi M. Effects of intracellular and extracellular concentrations of Ca²⁺, K⁺, and Cl^- on the Na⁺-dependent Mg²⁺ efflux in rat ventricular myocytes. Biophys J, 2006. 91:244-254 DOI:10.1529/biophysj.106.082495.

53.   Tashiro M, Tursun P, Konishi M. Intracellular and extracellular concentrations of Na⁺ modulate Mg²⁺ transport in rat ventricular myocytes. Biophys J, 2005.89:3235-3247 DOI: 10.1529/biophysj.105.068890.

54.   Tursun P, Tashiro M, Konishi M. Modulation of Mg²⁺ efflux from rat ventricular myocytes studied with the fluorescent indicator furaptra. Biophys J, 2005.88:1911-1924 DOI: 10.1529/biophysj.104.055517.